What Would Cause Someone to be Intolerant to Magnesium?

Magnesium intolerance, although relatively rare, can occur for various reasons. It’s important to note that true magnesium intolerance is not as common as other food intolerances, like lactose or gluten intolerance.

Here are some potential causes of magnesium intolerance or adverse reactions to magnesium.

What Would Cause Someone to be Intolerant to Magnesium?

People can be intolerant to magnesium because of GI problems, medications, nutrient deficiencies, etc. Listed below are 10 reasons why some people cannot tolerate magnesium.

Related Articles

Signs of Too Much Magnesium

Magnesium Taurate for Heart Palpitations

Cardiovascular Research ltd Magnesium Taurate

Omeprazole Magnesium Deficiency

Magnesium and Heart Failure

You cannot handle magnesium because of digestion problems.

Gastrointestinal Disorders:

Individuals with certain gastrointestinal disorders, such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD), may have difficulty absorbing magnesium properly.

This can lead to symptoms like diarrhea or abdominal cramps when magnesium is consumed.

Kidney Problems

The kidneys play a crucial role in regulating magnesium levels in the body.

If someone has kidney disease or impaired kidney function, they may not be able to excrete excess magnesium efficiently, leading to elevated levels in the blood and potential symptoms of magnesium intolerance.


Some medications, like certain diuretics, can affect magnesium absorption or excretion. If someone is taking medications that interfere with magnesium balance, it can result in symptoms of intolerance.

Allergic Reactions

In very rare cases, individuals may have an allergic reaction to magnesium-containing supplements or medications. This can manifest as hives, itching, or other allergic symptoms.

You cannot handle magnesium because of digestion problems.

Excessive Magnesium Intake

While magnesium is essential for health, excessive intake from supplements or certain foods can lead to symptoms of intolerance, such as diarrhea or stomach discomfort.

It’s essential to maintain an appropriate balance of magnesium in the diet.

Individual Sensitivity

Some individuals may simply have a heightened sensitivity to magnesium, leading to gastrointestinal discomfort or other symptoms when they consume magnesium-rich foods or supplements.

PCOS (Polycystic Ovary Syndrome)

PCOS is a hormonal disorder that can lead to irregular menstrual cycles, insulin resistance, and elevated androgen levels.

Insulin resistance associated with PCOS can affect magnesium metabolism.

When the body is resistant to insulin, it may have trouble transporting magnesium into cells, potentially leading to magnesium imbalance and intolerance symptoms.

Magnesium intolerant.

Prediabetes and Glucose Intolerance

Both prediabetes and glucose intolerance involve issues with blood sugar regulation. Individuals with these conditions may experience fluctuations in blood glucose levels.

Magnesium plays a role in glucose metabolism and insulin sensitivity. Therefore, disruptions in glucose regulation can impact magnesium utilization, potentially contributing to magnesium intolerance symptoms.

Depression and High Anxiety

Mental health conditions like depression and high anxiety can have physical effects on the body.

These conditions can lead to stress responses that alter magnesium levels. Chronic stress, common in anxiety and depression, can deplete magnesium levels in the body.

Low magnesium levels have been associated with increased susceptibility to mood disorders, potentially worsening symptoms of depression and anxiety.


Insomnia, the inability to sleep, can be both a symptom and a cause of magnesium imbalance.

Magnesium is known to play a role in regulating sleep patterns and promoting relaxation.

Deficiencies in magnesium can lead to sleep disturbances and difficulty falling asleep.

Conversely, chronic insomnia can lead to increased stress and anxiety, potentially exacerbating magnesium intolerance symptoms.

Solutions for Magnesium Intolerance

Magnesium is involved in over 300 processes in the body, including the heart. We need magnesium. Your heart can’t function without it. Let’s look at some ways that are hampering you from tolerating magnesium.

  1. Vitamin B6 (Pyridoxine): Vitamin B6 is essential for the conversion of magnesium into its active form within cells. This active form, called magnesium adenosine triphosphate (Mg-ATP), is involved in energy production and numerous enzymatic reactions in the body.
  2. Calcium: Magnesium and calcium work in tandem to regulate muscle contractions, including those in the heart. Maintaining a proper balance between these two minerals is critical for muscle function.
  3. Vitamin D: Vitamin D plays a role in magnesium absorption in the intestines. Without sufficient vitamin D, your body may have difficulty absorbing magnesium from the diet. Also, without sufficient magnesium, your body cannot absorb vitamin D.
  4. Potassium: Magnesium and potassium are both electrolytes that help maintain electrical impulses in nerves and muscles. They often work together to support muscle function and prevent cramps.
  5. Sodium: Sodium, another electrolyte, can influence magnesium levels. Maintaining an appropriate sodium balance is essential for overall electrolyte homeostasis, which can affect magnesium absorption and utilization.
  6. Zinc: Zinc is involved in the activation of magnesium-dependent enzymes. It also helps regulate the release of magnesium from storage sites in the body.
  7. Vitamin K: Vitamin K plays a role in the activation of a protein called osteocalcin, which is responsible for proper calcium utilization in bone tissue. Magnesium is indirectly involved in this process, as it influences calcium metabolism.
  8. Vitamin E: Vitamin E may help protect magnesium from oxidative damage, ensuring that it remains active and available for various physiological processes.
  9. Protein: Adequate protein intake is important for magnesium homeostasis, as magnesium is often bound to proteins in the body. This binding can affect magnesium’s bioavailability and distribution.
  10. Boron: Boron may facilitate the absorption of magnesium in the intestines. It can influence the transport of magnesium across cell membranes, allowing for increased uptake of magnesium from the digestive system into the bloodstream.
Why can't I tolerate types of magnesium?


In conclusion, magnesium is an essential mineral that plays a vital role in numerous physiological processes within the body. It is required for over 300 biochemical reactions, making it crucial for overall health. Magnesium is particularly important for heart health, bone health, muscle function, and energy production.

If you suspect magnesium intolerance or deficiency, it’s essential to consult with a healthcare professional for proper evaluation and guidance. They can recommend appropriate tests, dietary adjustments, and potential supplementation to address your specific needs.

Additionally, magnesium does not work in isolation but often requires cofactors like vitamin B6, calcium, vitamin D, and others to function effectively. Maintaining a balanced diet that includes these nutrients is key to supporting optimal magnesium utilization.




Leave a Comment

Healing Heart Disease Naturally (HHDN)
Follow by Email